2. Signaling Pathways
  3. Anti-infection
  4. Reverse Transcriptase

Reverse Transcriptase

Reverse Transcriptase

Related Products

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Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.

Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Reverse Transcriptase Related Products (259):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105372
    PNU-103657
    		Inhibitor
    PNU-103657 (Compound 13) is an orally active reverse transcriptase inhibitor (IC50 = 0.51 μM (WT)). PNU-103657 has antiviral activity. PNU-103657 can be used in research on infections and immune system diseases such as HIV infection.
    PNU-103657
  • HY-167135
    DPC-082
    		Inhibitor
    DPC-082 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. DPC-082 inhibits wild-type RF virus with an IC90 of 2.0 nM. DPC-082 inhibits various single and many multiple amino acid substituted HIV-1 mutant viruses.
    DPC-082
  • HY-131603
    Lamivudine triphosphate
    		Inhibitor
    Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA.
    Lamivudine triphosphate
  • HY-N10411
    Morin 3-O-β-D-glucopyranoside
    		Inhibitor
    Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
    Morin 3-O-β-D-glucopyranoside
  • HY-14922
    Fosalvudine tidoxil
    		Inhibitor
    Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection.
    Fosalvudine tidoxil
  • HY-19493
    Niglizin
    		Inhibitor
    Niglizin is a noncompetitive inhibitor of reverse transcriptase. Niglizin can effectively suppress the HIV replication and shows synergetic effect companied with Zidovudine (HY-17413). Niglizin can be used for the research of HIV infection.
    Niglizin
  • HY-117582
    Elvucitabine
    		Inhibitor
    Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection.
    Elvucitabine
  • HY-W777351
    Etravirine-13C3
    Etravirine-13C3 (R165335-13C3) is the 13C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
    Etravirine-<sup>13</sup>C<sub>3</sub>
  • HY-14266S
    Dapivirine-d11
    		Inhibitor
    Dapivirine-d11 is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
    Dapivirine-d<sub>11</sub>
  • HY-116694
    Digallic acid
    		Inhibitor
    Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus.
    Digallic acid
  • HY-152160
    HIV-1 inhibitor-50
    		Inhibitor
    HIV-1 invistor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC50=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC50s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains.
    HIV-1 inhibitor-50
  • HY-N16888
    Peruvianoside II
    		Control
    Peruvianoside II is a flavanone glucoside compound. Peruvianoside II shows no inhibitory activity against both HIV-1 reverse transcriptase and HIV-1 integrase at concentrations below 100 μM. Peruvianoside II can be extracted from the leaves of Thevetia peruviana.
    Peruvianoside II
  • HY-10574AS
    Rilpivirine-d6 hydrochloride
    Rilpivirine-d6 (hydrochloride) is the deuterium labeled Rilpivirine hydrochloride.
    Rilpivirine-d<sub>6</sub> hydrochloride
  • HY-105386
    HI-280
    		Inhibitor
    HI-280 is a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor. HI-280 can be used for the research of infection.
    HI-280
  • HY-116154
    Metacavir
    		Inhibitor
    Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
    Metacavir
  • HY-10572R
    Efavirenz (Standard)
    		Inhibitor
    Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
    Efavirenz (Standard)
  • HY-14266R
    Dapivirine (Standard)
    		Inhibitor
    Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
    Dapivirine (Standard)
  • HY-118731
    TNK-6123
    		Activator
    TNK-6123 is a potent Emivirine (HY-15353) analogue with improved activity against drug-resistant HIV mutants. TNK-6123 improves activity against Lys103Asn mutant RT.
    TNK-6123
  • HY-19869
    VRX-480773
    		Inhibitor
    VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS.
    VRX-480773
  • HY-17423R
    Abacavir (Standard)
    		Inhibitor
    Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir (Standard)